Blar i forfatter "Kuklin, Vladimir"

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    • Clinical validation of a new “call-out algorithm” for postoperative pain management: a two-center prospective randomized trial 

      Kuklin, Vladimir; Dybvik, Lisa; Skraastad, Erlend Johan; Yeltayeva, Aigerim; Konkayev, Aidos; Musaeva, Tatiana; Zabolotskikh, Igor; Bjertnaes, Lars J.; Dahl, Vegard; Ræder, Johan (Conference object; Konferansebidrag, 2017-05-06)
      The goal of modern postoperative pain management is to relieve pain while keeping side effects to a minimum. Still, in recent investigations, between 20% and 40% of all postoperative patients report high levels of pain after surgery, while 20-30% experience adverse effects of opioid analgetics [1,2]. In a study, in which the hospitals had introduced pain management guided by the patients' own ...

    • Development and validation of the Efficacy Safety Score (ESS), a novel tool for postoperative patient management 

      Skraastad, Erlend Johan; Ræder, Johan; Dahl, Vegard; Bjertnæs, Lars J.; Kuklin, Vladimir (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-28)
      Background: <br> Several reports have shown that postoperative monitoring of general safety and quality issues, including pain treatment, after discharge from recovery is often non-systematic and inadequate. We suggest a new score with assessment of key recovery parameters, as a supportive tool for postoperative care and a call-out algorithm for need of extra help. The aim of this investigation ...

    • Effects of morphine or ketamine in rats with asphyxial cardiac arrest: a pilot study 

      Kuklin, Vladimir; Kondratyev, Timofey; Konkayeva, Maya; Akhatov, Nurlan; Sovershaev, Mikhail; Konkayev, Aidos; Tveita, Torkjel (Conference object; Konferansebidrag, 2017-05-06)
      Acute hypoxia results in uncontrolled release of glutamate and the consequent stimulation of N-methyl-D-aspartate (NMDA) receptors, which affects the whole ionic homeostasis and finally activates apoptosis of neurons. A potential therapeutic approach to prevent this sequence of events is a blockade of NMDA receptors. Meanwhile, in different models of acute hypoxia, activation of delta-opioid ...

    • Influence of a New “Call-Out Algorithm” for Management of Postoperative Pain and Its Side Effects on Length of Stay in Hospital: A Two-Centre Prospective Randomized Trial 

      Dybvik, Lisa; Skraastad, Erlend Johan; Yeltayeva, Aigerim; Konkayev, Aidos; Musaeva, Tatiana; Zabolotskikh, Igor; Bjertnaes, Lars J.; Dahl, Vegard; Ræder, Johan; Kuklin, Vladimir (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-10)
      Background. We recently introduced the efficacy safety score (ESS) as a new “call-out algorithm” for management of postoperative pain and side effects. In this study, we report the influence of ESS recorded hourly during the first 8 hours after surgery on the mobility degree, postoperative nonsurgical complications, and length of hospital stay (LOS). Methods. We randomized 1152 surgical patients ...

    • The influences of morphine or ketamine pre-treatment on hemodynamic, acid-base status, biochemical markers of brain damage and early survival in rats after asphyxial cardiac arrest 

      Kuklin, Vladimir; Akhatov, Nurlan; Kondratiev, Timofei; Konkayev, Aidos; Baigenzhin, Abai K.; Konkayeva, Maiya; Karibekov, Temirlan; Barlow, Nicholas; Tveita, Torkjel; Dahl, Vegard (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-20)
      <i>Background</i> - In different models of hypoxia, blockade of opioid or N-methyl-D-aspartate (NMDA) receptors shows cardio- and neuroprotective effects with a consequent increase in animal survival. The aim of the study was to investigate effects of pre-treatment with Morphine or Ketamine on hemodynamic, acid-base status, early survival, and biochemical markers of brain damage in a rat model of ...